Effects of sodium hyaluronate on experimental osteoarthritis in rabbit knee joints.

Chitosan-Hyaluronate Hybrid Gel Intraarticular Injection Delays Osteoarthritis Progression and Reduces Pain in a Rat Meniscectomy Model as Compared to Saline and Hyaluronate Treatment

Chitosan-Hyaluronate hybrid gel (CHHG) is a self-forming thermo-responsive hydrogel. The current study was undertaken in order to assess the effect of CHHG on rat's surgically induced osteoarthritis. Methods. Thirteen rats were included in the study. In all rats weight-bearing was assessed using a Linton Incapacitance tester. All rats underwent bilateral medial partial meniscectomy. Four rats r...

A double blind randomized active-controlled clinical trial on the intra-articular use of Md-Knee versus sodium hyaluronate in patients with knee osteoarthritis ("Joint").

BACKGROUND To evaluate the clinical outcomes of a group of patients affected by knee osteoarthritis (OA) treated with MD-Knee (Guna S.p.a., Milan, Italy) versus a group of patients treated with sodium hyaluronate. METHOD This non-inferiority prospective randomized controlled trial involved 60 patients affected by knee OA, grade 2-3 of Kellgren-Lawrence scale. The MD-Knee Group, Group A (n = 2...

Long-term efficacy and safety of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee.

OBJECTIVE This prospective cohort study evaluated the long-term efficacy and safety of 5 weekly intra-articular (i.a.) injections of sodium hyaluronate (Hyalgan) in 76 patients (92 knees) with moderate to severe osteoarthritis (OA) of the knee whose pain was not controlled by conventional measures. RESULTS Thirteen patients had a repeat treatment course. A total of 72% of patients achieved > ...

Effects of backward gait training on Excursions of Lower Limb Joints of patients with medial knee Osteoarthritis

 Aims and background: The aim of this study was to investigate effects of backward gait training on Excursions of Lower Limb Joints in man Patients with medial knee Osteoarthritis. Materials and methods: The subjects were 21 healthy men and 42 male patients with knee osteoarthritis who were divided into experimental and control groups according to the Kellgren and Lawrence radiologic scale and ...

Author's response to reviews Title: Intra-articular Injections of Sodium Hyaluronate (Hyalgan(R)) in Osteoarthritis of the Knee A Randomized, Controlled, Double-Blind, Multicenter Trial in the Asian Population Authors: